JOURNAL 2191
Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 5 September-October
Year: 2022 Issue: 5 September-October
PAGES
p.426 - 432
p.426 - 432
STATISTICS
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Viewed 2111 times.
GRAPHICAL ABSTRACT
ABSTRACT
A phytochemical investigation of the stems of Myoporum bontioides (Sieb. et Zucc.) A. Gray, a semi-mangrove plant distributed along coastlines of north-eastern Vietnam and some Asian countries led to the isolation of a new iridoid glucoside (1), named myobontioside E, together with fourteen known compounds (2-15). Their structures were elucidated by means of HR ESI-MS, 1D and 2D NMR spectroscopy as well as comparison with the data reported in the literature. The cytotoxic effects on 8505C, MKN7, HT29, and T24 cell lines were assessed using SRB assay. Only iridoid 2 exhibited weak cytotoxicity against all tested cell lines with IC50 values ranging from 60.19 to 69.14 µM.
KEYWORDS- Myoporum bontioides
- Myoporaceae
- iridoid glucoside
- dammarane saponin
- cytotoxicity
