JOURNAL 2250
Records of Natural Products
Year: 2022 Issue: 5 September-October
p.433 - 442
Viewed 2126 times.
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Youngseok Kim
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Ha-neul Ju
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Pilju Choi
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Taejung Kim
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Young-tae Park
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Dae-hee Lee
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Jungyeob Ham
GRAPHICAL ABSTRACT
ABSTRACT
The compounds hydrangenol and hydrangenol 8-O-glucoside are abundant in Hydrangea macrophylla. This study investigated the effects of hydrangenol and hydrangenol 8-O-glucoside derived from H. macrophylla on atopic dermatitis (AD). Compared with hydrangenol 8-O-glucoside, hydrangenol resulted in more potent inhibition of interleukin 4 (IL-4) gene expression and β-hexosaminidase release, as well as more potent inhibition of the phosphorylation of signal transducer and activator of transcription 6 (STAT6). Ultra High-Performance Liquid Chromatography (UHPLC), the concentrations of hydrangenol were found to be lower than the concentration of hydrangenol 8-O-glucoside in H. macrophylla extracts. To increase the hydrangenol content of H. macrophylla extract, component conversion methods were studied. Conclusion, microwave processing was found to be the optimal method for deglycosylation.
KEYWORDS- Hydrangea macrophylla
- hydrangenol
- hydrangenol 8-O-glucoside
- atopic dermatitis
- microwave irradiation
