JOURNAL 2593
Records of Natural Products
Year: 2023 Issue: 2-March-April
p.367 - 371
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GRAPHICAL ABSTRACT
ABSTRACT
The marine-derived fungus SCZ-1 was cultured on a rice solid medium. The fermented materials was extracted using ethyl acetate to afford an extract, which was separated by repeated column chromatography to afford three polyketides and five alkaloids, including 2 new polyketides (1 and 2). The known compounds were identified to be penipyrol A (3), cyclopenin (4), cyclopenol (5), terretrione D (6), viridicatol (7), and viridicatin (8). The structures of 1 and 2 were determined by extensive analyses of spectroscopic data (1D and 2D NMR, and HRESIMS). The absolute configuration of 2 was assigned by comparing the experimental and calculated ECD spectra. Compound 1, bearing a two-carbon side chain at C-2, is seldom found among isocoumarins. The metabolites were screened for their inhibitions toward a-glucosidase, only compound 8 showed weak inhibitory effect with an IC50 value of 548 mM.
KEYWORDS- Marine fungus
- Penicillium sp.
- new polyketides
