JOURNAL 2466
Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 2-March-April
Year: 2023 Issue: 2-March-April
PAGES
p.265 - 274
p.265 - 274
STATISTICS
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Viewed 2320 times.
GRAPHICAL ABSTRACT
ABSTRACT
Two new sesquiterpenes (1R,5R,6R)-11-hydroxyl-drocostuslactone (1) and (1R,10S)- gibberodione A (2) were acquired from the leaves of Dalbergia odorifera. The structures of two new sesquiterpenes were revealed by broad NMR exploration, and X-ray crystallography analyses. In addition, the bioactivity assay showed that two compounds had potential anti-inflammatory activity with less toxicity (their IC50 values were 107.2 ± 4.02 and 54.64 ± 1.89 μg/mL), could significantly decrease the production of NO (P<0.01) with 8~16 and 1~2 μg/mL and inhibited LDH (P<0.01) with 1~16 and 1~2 μg/mL in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, respectively.
KEYWORDS
- Dalbergia odorifera
- sesquiterpenoids
- anti-inflammatory activity
