JOURNAL 3781
Records of Natural Products
Year: 2026 Issue: 3
p.4 - 4
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GRAPHICAL ABSTRACT
ABSTRACT
Eight compounds were isolated from the ethyl acetate extract of the Diaporthe phaseolorum fermentation products, comprising five polyketide derivatives (1–5), one chromene (6), one chromone (7), and one tetralone (8). Among these, compounds 1 and 6 were identified as previously undescribed. Notably, compound 6 features a unique C12 chromone skeleton, representing only the second reported example of such a framework. The structures and spatial configurations of all compounds were elucidated through comprehensive analysis of HR-MS, NMR, and quantum chemical calculations supported by DP4+ analysis. In vitro anti-inflammatory activity screening revealed that none of the isolated compounds (1–8) inhibited nitric oxide (NO) production in mononuclear macrophages.
KEYWORDS- Diaporthe phaseolorum
- Polygonatum cyrtonema Hua
- polyketide
- chromene
