Organic Communications Articles

An efficient and novel one-pot synthesis of 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature stirring. The six-membered N,O-heterocyclic skeleton was constructed via 1-benzyl-3-methyl imidazolium hydrogen sulphate [bnmim] [HSO4] promoted Mannich type reaction.

Enaminones 3 and 4, precursors of 4-thiazolidinones, were  prepared by condensing tetronic acid (1a) and 4-hydroxy 6-methyl pyrone (1b) respectively with thiosemicarbazide derivatives 2 in refluxing ethanol.  The 4-thiazolidinones 6, 7 derivatives were obtained by reacting compounds 3 or 4 with ethyl 2- bromo propionate 5 in the presence of anhydrous sodium acetate in ethalonic medium. Similarly, 9 products were synthesized by action of benzyl 2-bromo acetate 8 on 3.

The cyclic oxadiazolediyl dioxachlorophosphine precursor on subsequent reaction with various alcohols underwent halide displacement to give 2-substituted diaza phospholes. These phospholes on oxidative addition with di hydroxy alcohols form corresponding phosphoranes The antimicrobial activities of these compounds were evaluated and they exhibited significant antimicrobial activity.