Organic Communications Articles

EISSN: 1307-6175

Issue: 2 April-June

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Organic Communications

Year: 2010 Volume: 3 Issue:2 April-June

Original Article

1) Synthesis and antimicrobial evaluation of 2-(2-butyl- 4-chloro-1H-imidazol-5-yl-methylene)-substituted-benzofuran-3-ones

Org. Commun. (2010) 3:2 ; 22 - 29

by Bhaskar S. Dawane, Shankaraiah G. Konda, Namdev T. Khandare, Santosh S. Chobe, Baseer M. Shaikh, Ragini G. Bodade and Vishwas D. Joshi

In the present study, the oxidation of 3-(4-chloro-1H-imidazol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1-ones with mercuric(II) acetate in in polyethylene glycol (PEG-400) gave the corresponding 2-((4-chloro-1H-imidazol-5-yl)methylene)benzofuran-3(2H)-ones. Newly synthesized compounds were tested for their in vitro antimicrobial activity.

Keywords

PEG-400 2’-hydroxy chalcones benzofuran-3-ones antimicrobial activity.

Original Article

2) Novel 3-[4-(diethylamino)phenyl]-4-substituted-1-ylsulfonyl) sydnones: Synthesis, characterization and antimicrobial studies

Org. Commun. (2010) 3:2 ; 30 - 38

by Shahrukh T. Asundaria, Nikul S. Patel and Keshav C. Patel

Ten novel 3-[4-(diethylamino)phenyl]-4-substituted-1-ylsulfonyl)sydnones (8a-j) have been synthesized. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. Compound 3-[4-(Diethylamino)phenyl]-4-(piperazin-1-ylsulfonyl)sydnone (8b) and 3-[4-(Diethylamino)phenyl]-4-[(4-methylpiperazin-1-yl)sulfonyl]sydnone (8d) exhibited highest activity against all tested microorganisms. Some compounds were found effectively active against tested organisms.

Keywords

Sydnone sulfonamide characterization antimicrobial.