Organic Communications Articles

Various 4'-hydroxy-3',5'-dinitro substituted chalcones 1 and S-benzylthiouronium chloride (SBT) 2 in the presence of DMF-organic bases (morpholine/ pyrrolidine/ piperidine) gave 4,6-diaryl-2-(4-morpholinyl / 1-pyrrolidinyl /1-piperidinyl)- pyrimidines 4, 5and 6 in a facile one-pot conversion. In an another attempt reactants 1 and 2 yielded intermediate 2-benzylthiopyrimidines 3, in presence of DMF, which on treatment with heterocyclic secondary amines gave products 4, 5 and 6 in an alternate two-step process.

Imidazolines and Benzimidazoles have been efficiently synthesized in high yields by treatment of 1,2-diamine with aldehydes using the metal co-ordinate complex K 4[Fe(CN) 6] as a catalysis. The method was carried out under solvent free condition via oxidation of carbon-nitrogen bond. The process is green, mild and inexpensive.

A series of new di- and triorganotin(IV) complexes of monoisopropyl and mono n-propyl glutarate have been synthesized and characterized by 1H- 13C- 119Sn-NMR, UV, IR and Mass spectrometry. The spectroscopic investigation demonstrated that the carboxylate group acts as a bidentate ligand in diorganotin(IV) and as a monodentate ligand in triorganotin(IV) compounds. Biological evaluation against various microorganisms indicates that the diorganotin(IV) complexes are slightly less reactive than triorganotin(IV) complexes.

Design, synthesis and characterization of four novel series of Zafirlukast analogs are described. The modifications are substitution on indole nitrogen, C-5 position of indole moiety and amide nitrogen of zafirlukast.