Organic Communications Articles

A simple and efficient method has been developed for the synthesis of β-amino carbonyl compounds from aromatic ketones, aldehydes and amines by Mannich reaction in the presence of amberlyst-15 as a reusable heterogeneous catalyst at room temperature under solvent-free conditions. The noteworthy advantages of the present method are short reaction times, good product yields, simple procedures and use of non-toxic catalyst.

The Click reaction between the electronically divergent triazole compounds 4-((l-(4-(tert-butyl)benzyl)-1H-l,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrobenzamides (8a-e) with different aldehydes using Na 2S 2O 4 in DMSO was performed to obtain hybrid of quinazolinone-triazole derivatives (10a-o). All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and screened for their antibacterial activities strains using paper disc method. The compounds (10 a-o) were evaluated for their antibacterial activity against human pathogenic organism Escherichia Coli, Staphylococcus aureus (Table 1). The investigation of antibacterial screening data reveal that 10e, 10f, 10g, 10jand 10n were highly active against E. coli, where as 10b, 10d, 10j,10k and 10o showed least activity. Compounds 10b, 10e, 10f, 10g, 10i, 10k and 10n showed high activity against S. aureus, where as compounds 10d, 10j, 10o showed least activity. Compounds 10c, 10h, 10l and 10o were inactive against both organisms employed.