Organic Communications Articles

We report a series of novel 4H-furo[3,2–c]pyran-4-one derivatives. Structures of synthesized compounds were determined by the IR, NMR, elemental analysis and X-ray diffraction method. All the compounds were tested for genotoxicity in human lymphocytes cultures. Sister chromatid exchange (SCE), micronucleus (MN), mitotic index (MI) and replication index (RI) tests are used in toxicological screening for potential cytotoxic and genotoxic effects. According to the results of the genotoxic tests, the 4H-furo[3,2–c]pyran-4-one derivatives induce the frequencies of these parameters. The results showed that these compounds are potential genotoxic and cytotoxic compounds at high concentrations (especially 1 and 2 mg/mL).

Schiff’s base1-[(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)]ethanone thiosemicarbazone (compound 1A) wasprepared by condensation of 1-(2,4-difluorophenyl)-2- [1 (H)-1,2,4-triazol-1-yl]ethanone (1)with thiosemicarbazide. The compound 1A, on reaction with α-halogenoketones yielded 1-(2, 4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1-yl] ethanone [2-[4-halogenophenyl] thiazolyl]hydrazone.Anti-fungal activity of all the compounds has been tested against four fungal organism: C. albicans , Colletotrichum spp., A. nigar and Fusarium spp. commonly responsible for fungal infections in Bangladesh.

Yttrium (III) chloride catalyzed Mannich reaction of aldehydes with ketones and amines in acetonitrile at reflux temperature to give various β-amino carbonyl compounds in very good yields.

A simple and efficient protocol has been developed for the synthesis of Hantzsch pyridines. In the reported synthesis, a variety of aldehydes undergo smooth condensation reaction with ethyl acetoacetate and ammonium acetate in presence of Germanium (IV) iodide in acetonitrile. This method is applicable to a variety of substrates to afford the corresponding 1,4-dihydropyridines in one-pot reaction in excellent yields.

A number of new substituted 1,2,4,9,10,12-hexaazadispiro[4.2.4.2]tetra-deca-2,10-dienes have been obtained from the reaction of 1,4-cyclohexanedione hydrazones having acetyl, benzoyl, ethoxycarbonyl and methoxycarbonyl groups with appropriate nitrilimines. The microanalysis and spectral data of the synthesized compounds are in full agreement with their molecular structure. The microbial features of the synthesized compounds were studied by a known method.