Synthesis of β-enaminoesters from β-ketoesters and amines by solvent-drop grinding approach in PEG 400

Original Article

JOURNAL 3334

Organic Communications

VOLUME & ISSUE

Year: 2024 Issue: 4 October-December

PAGES

p.241 - 248

DOI ADDRESS

http://doi.org/10.25135/acg.oc.178.2409.3334

STATISTICS

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AUTHORS

Swanand S. Mukhedkar
Balaji Digambar Kokane
Jitendra Hanmantrao Deshmukh
Shivraj Shankarrao Anjanikar

GRAPHICAL ABSTRACT

ABSTRACT

An effective catalytic system for the synthesis of β-enaminoesters from β-ketoesters under mechanochemical conditions using mortar and pestle in recyclable PEG 400 as solvent-drop approach was developed. This method has a number of benefits, including shorter reaction times, use of inexpensive recyclable solvent cum catalyst system, compatible reaction conditions, and high product yields. ©2024 ACG Publications. All rights reserved.

KEYWORDS

β-ketoesters
β-enaminoesters
grinding
solvent-drop
PEG 400
mechanochemical catalysis

SUPPORTING INFORMATION

Supporting Information

Download File A5-178-OC-2409-3334-SI.pdf (1.23 MB)