Organic Communications Articles

A one pot, four component synthesis of 1, 2, 4-trisubstituted imidazoles is described by reacting a mixture of bromo dehydroacetic acid, aromatic aldehyde, benzyl amine, and ammonium acetate in dry alcohol. All the synthesized compounds were characterized by their analytical and spectral data.

1,3-Diamine 1 on condensation with different halogeno substituted benzaldehydes 2a-p under microwave irradiation affords novel series of bis-schiff bases 3a-p. Structures of the newly synthesized bis-Schiff bases established on the basis of spectroscopic data. Further, all compounds screened for antimicrobial activity against Staphylococus aureus, Escherchia coli, Aspergillus niger and Aspergillus flavus. Most of the titles compounds show potent activity.

In the present communication a series of novel indeno-pyrazole derivatives were synthesized by the reaction of α, β-unsaturated ketones with phenyl hydrazine in polyethylene glycol-400 (PEG-400) and few drop of acetic acid. The newly synthesized compounds were characterized and confirmed by IR, 1H-NMR, 13C-NMR and mass spectral data. The results obtained indicate the significance of indeno-pyrazole derivatives as potent scaffold for designing novel and broad spectrum antimicrobials.

A facile and regioselective synthesis of 1, 4-benzothiazines was achieved with a variety of a -cyano a -alkoxy carbonyl epoxides and 2-aminothiophenol in the presence or no of HCl in the reaction medium. The structures of the newly synthesized compounds were confirmed by spectral studies.