Organic Communications Articles

CuO-Al2O3 catalyzed one-pot oxidation with O2 and self-coupling of benzylamines to give Nbenzylbenzaldimines was described in good yields. Similarly, secondary dibenzylamines were oxidized to Nbenzylbenzaldimines.

Here a new class of 1, 3, 4-thiadiazoles which are incorporating with isoxazolo-thiazole moieties were synthesized by the reaction of chalcone derivatives of [1, 3, 4] thiadiazol-2-yl)-thiazolidin-4-one with hydroxylamine hydrochloride. The chemical structures of these compounds were confirmed by IR, NMR (1H & 13C) and mass spectral studies. The new synthesized compounds were evaluated for their antimicrobial activity. The final results revealed that some of the compounds were exhibited well antimicrobial activity compared to the
standard drugs.

Starting from maleimidederivatives, a series of 2-thioxoimidazolidinones was prepared through two different procedures. These syntheses have achieved in two steps via reaction between maleimide derivatives 1,semicarbazide hydrochloride 9 and isothiocyanates5,the best results being obtained under acid conditions (AcOH or heteropolyacid in ethanol or acétonitrile). The synthesized compounds 11a-f and substituted thiohydantoins 6a-h, 8a-h were screened for their in vitro anti-bacterial activity against four bacterial strains.

7-hydroxy 4-styryl coumarin derivatives were synthesized by Knovengel condensation of 7-hydroxy 4-methyl coumarin with aldehydes by using novel and reusable catalyst bleaching earth clay (pH12.5) in PEG- 400 as green reaction solvent, followed by the Mannich reaction. The synthesized compounds were evaluated for their in vitro antihelmintic activity and it was found that the synthesized compounds showed good antihelmintic activity.